<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:0f9c9738-d9b2-4b1d-b68e-63f9c0c47378,g:6bcf93cf-8280-4d62-880d-5f43a4a3418b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.corcept.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="cort-20241231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_99257d44-ee9d-4731-8d2f-83d6876ebd30" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_bac00a2e-082f-4eb7-8c2d-2a2fc45ab2b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_99257d44-ee9d-4731-8d2f-83d6876ebd30" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_bac00a2e-082f-4eb7-8c2d-2a2fc45ab2b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_cf794a36-6c3c-4fef-a50e-87b7c4388f43" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_99257d44-ee9d-4731-8d2f-83d6876ebd30" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_cf794a36-6c3c-4fef-a50e-87b7c4388f43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b47cf6bd-9788-4e6b-bced-924d62591b94" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_99257d44-ee9d-4731-8d2f-83d6876ebd30" xlink:to="loc_us-gaap_LiabilitiesCurrent_b47cf6bd-9788-4e6b-bced-924d62591b94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_598759d8-e955-49f5-835d-485ceeac6412" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_e17aacb5-b478-485d-b69f-8629dd9b9874" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_598759d8-e955-49f5-835d-485ceeac6412" xlink:to="loc_us-gaap_Liabilities_e17aacb5-b478-485d-b69f-8629dd9b9874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_d65cbfe1-e9b3-421d-87df-db7b11e496b5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_598759d8-e955-49f5-835d-485ceeac6412" xlink:to="loc_us-gaap_CommitmentsAndContingencies_d65cbfe1-e9b3-421d-87df-db7b11e496b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_e02c60a0-5781-4fff-ad36-bb9f0890526d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_598759d8-e955-49f5-835d-485ceeac6412" xlink:to="loc_us-gaap_StockholdersEquity_e02c60a0-5781-4fff-ad36-bb9f0890526d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3f9c4175-6e2a-4d78-af8b-913bcec2c4d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3f9c4175-6e2a-4d78-af8b-913bcec2c4d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_fbce90b1-1600-4f4e-ad00-7ffbcac7c68a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_fbce90b1-1600-4f4e-ad00-7ffbcac7c68a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e692f521-3e92-41dd-be49-a5fbe128e32e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_e692f521-3e92-41dd-be49-a5fbe128e32e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_9d4a74e0-4cb0-44af-bc7a-acbf671c834c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_InventoryNet_9d4a74e0-4cb0-44af-bc7a-acbf671c834c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_282efb7b-bc6d-40f4-b4ce-a1a3e97be0b0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_282efb7b-bc6d-40f4-b4ce-a1a3e97be0b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyReceivableCurrent_a32e66a8-324b-4ca7-a18d-04666fef5c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyReceivableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_38a71f56-2876-4121-b294-b637c9ac9a9b" xlink:to="loc_us-gaap_LossContingencyReceivableCurrent_a32e66a8-324b-4ca7-a18d-04666fef5c6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_fd2d37f7-c59f-4016-9ac3-7e74e211deb3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_AssetsCurrent_fd2d37f7-c59f-4016-9ac3-7e74e211deb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_4f99ccd2-8e76-410b-9710-1630fd4366df" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_InventoryNoncurrent_4f99ccd2-8e76-410b-9710-1630fd4366df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_488b00fe-3b37-4555-afdd-677773f7455e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_488b00fe-3b37-4555-afdd-677773f7455e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_980c577c-5eaf-4b38-9fb7-71166a6a78c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_980c577c-5eaf-4b38-9fb7-71166a6a78c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_0f7a6033-5ba6-48a6-9b0a-95428036e402" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_0f7a6033-5ba6-48a6-9b0a-95428036e402" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_6437d866-b8d7-4525-b38b-6d4bbc486b86" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_6437d866-b8d7-4525-b38b-6d4bbc486b86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_381b48d0-6b8e-4908-bab2-73f02e341680" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8119a62c-7584-4684-a45b-9e16521c579f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_381b48d0-6b8e-4908-bab2-73f02e341680" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_25867ae1-5e43-4adf-9fc4-5d62c1756668" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:to="loc_us-gaap_AccountsPayableCurrent_25867ae1-5e43-4adf-9fc4-5d62c1756668" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedResearchAndDevelopmentExpensesCurrent_7fc7fb3f-d17a-4e69-8e8e-3d15461f2a2d" xlink:href="cort-20241231.xsd#cort_AccruedResearchAndDevelopmentExpensesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:to="loc_cort_AccruedResearchAndDevelopmentExpensesCurrent_7fc7fb3f-d17a-4e69-8e8e-3d15461f2a2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0fdc3a77-d078-43ae-9e99-37be23cc74e3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_0fdc3a77-d078-43ae-9e99-37be23cc74e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_dead850a-aaf2-4dec-80cb-a3c6feae0f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_dead850a-aaf2-4dec-80cb-a3c6feae0f9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualCarryingValueCurrent_2a9c8164-1737-4f0a-bb50-7cea82c638b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyAccrualCarryingValueCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_61e0a558-b866-40c7-b9ff-a54f9e35f4ac" xlink:to="loc_us-gaap_LossContingencyAccrualCarryingValueCurrent_2a9c8164-1737-4f0a-bb50-7cea82c638b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValueOutstanding_08dfd4d3-c988-4528-bd4a-9e833bfdc3e3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValueOutstanding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_PreferredStockValueOutstanding_08dfd4d3-c988-4528-bd4a-9e833bfdc3e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_a8c0d8cf-5972-4c60-a74e-b8e942d22e22" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_CommonStockValueOutstanding_a8c0d8cf-5972-4c60-a74e-b8e942d22e22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_6572857c-a71e-446b-a336-777903ceb8bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_TreasuryStockCommonValue_6572857c-a71e-446b-a336-777903ceb8bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_e00e9e6b-3585-4182-85b3-5639ff7c2d62" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_AdditionalPaidInCapital_e00e9e6b-3585-4182-85b3-5639ff7c2d62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1b5395bf-378b-43ca-a879-63de73b35e1b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1b5395bf-378b-43ca-a879-63de73b35e1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0e2ad327-0a29-43fa-9913-632921c79f00" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d625d61-1584-44e2-859e-62a8f441191c" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_0e2ad327-0a29-43fa-9913-632921c79f00" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="cort-20241231.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_f0a9eda6-d3ee-400b-976e-054fd2b13f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e7b68b56-122e-40b6-843c-57a5f6b9c456" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_f0a9eda6-d3ee-400b-976e-054fd2b13f3f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e7b68b56-122e-40b6-843c-57a5f6b9c456" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_c22c3752-5905-4657-b2da-46a7aa32454a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_f0a9eda6-d3ee-400b-976e-054fd2b13f3f" xlink:to="loc_us-gaap_CostsAndExpenses_c22c3752-5905-4657-b2da-46a7aa32454a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_26f44b94-eff5-4d3d-a863-3e3f05601bbb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_0d3e43bb-c086-4403-8834-b05d33d3a987" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_26f44b94-eff5-4d3d-a863-3e3f05601bbb" xlink:to="loc_us-gaap_OperatingIncomeLoss_0d3e43bb-c086-4403-8834-b05d33d3a987" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_76f64f51-c2be-4b85-9b6c-f35a4b22c68f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_26f44b94-eff5-4d3d-a863-3e3f05601bbb" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_76f64f51-c2be-4b85-9b6c-f35a4b22c68f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_56bdedf2-d4ed-457d-9924-263d4e01b6f0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_56bdedf2-d4ed-457d-9924-263d4e01b6f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_f4a7278b-8b63-4f2a-b0bf-25cdd272dbe1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_f4a7278b-8b63-4f2a-b0bf-25cdd272dbe1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_db7fd691-10e5-4a4a-9151-24afe3edc813" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_db7fd691-10e5-4a4a-9151-24afe3edc813" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_e6fd961e-75d3-4f0d-abbf-f21ee54e156f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:to="loc_us-gaap_LitigationSettlementExpense_e6fd961e-75d3-4f0d-abbf-f21ee54e156f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InsuranceRecoveries_2d0cfb27-df21-4e1d-9fb0-38eefe37d7d3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InsuranceRecoveries"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_cda30c63-7393-4274-874e-e80395a8798c" xlink:to="loc_us-gaap_InsuranceRecoveries_2d0cfb27-df21-4e1d-9fb0-38eefe37d7d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_05b571a6-c01b-4dc9-88ef-2943bcdb6961" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_93dc0129-4528-4eed-82a7-67b831bb4fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_05b571a6-c01b-4dc9-88ef-2943bcdb6961" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_93dc0129-4528-4eed-82a7-67b831bb4fa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_cc6df519-af16-4fd1-abff-0d4f57189ab5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_05b571a6-c01b-4dc9-88ef-2943bcdb6961" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_cc6df519-af16-4fd1-abff-0d4f57189ab5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="cort-20241231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_0570262d-a254-4a94-a4b4-817fc4e67c79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_cc19a79d-95f9-4589-8514-a816fa0759e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_0570262d-a254-4a94-a4b4-817fc4e67c79" xlink:to="loc_us-gaap_NetIncomeLoss_cc19a79d-95f9-4589-8514-a816fa0759e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_b47a3664-d7e0-4a6a-ac67-004e16105552" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_0570262d-a254-4a94-a4b4-817fc4e67c79" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_b47a3664-d7e0-4a6a-ac67-004e16105552" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_3a302ade-fb4b-454b-9802-5f909616dba3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_0570262d-a254-4a94-a4b4-817fc4e67c79" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_3a302ade-fb4b-454b-9802-5f909616dba3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="cort-20241231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d50e74ba-653d-42d1-8874-156f7f91634d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_37089623-3492-4642-a0a7-d48cc5a75079" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d50e74ba-653d-42d1-8874-156f7f91634d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_37089623-3492-4642-a0a7-d48cc5a75079" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_96e1e618-433d-408d-8b72-16fb8214325f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d50e74ba-653d-42d1-8874-156f7f91634d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_96e1e618-433d-408d-8b72-16fb8214325f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_30acbbca-bf99-48f2-b1c5-f97184a2abfa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d50e74ba-653d-42d1-8874-156f7f91634d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_30acbbca-bf99-48f2-b1c5-f97184a2abfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_PaymentsForRepurchaseOfCommonStockInConnectionWithTenderOffer_9bdd3e65-54b4-4bd7-b322-3e9804d4edfc" xlink:href="cort-20241231.xsd#cort_PaymentsForRepurchaseOfCommonStockInConnectionWithTenderOffer"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:to="loc_cort_PaymentsForRepurchaseOfCommonStockInConnectionWithTenderOffer_9bdd3e65-54b4-4bd7-b322-3e9804d4edfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_7f7e5522-82b1-4cc6-ae73-2ae617559c18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:to="loc_us-gaap_ProceedsFromStockPlans_7f7e5522-82b1-4cc6-ae73-2ae617559c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_e6b484d6-4c10-440e-9599-6979dd763615" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_e6b484d6-4c10-440e-9599-6979dd763615" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_051e2e1f-7dea-4cf7-a961-d7946b8bc52f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_051e2e1f-7dea-4cf7-a961-d7946b8bc52f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_e6f0b860-e85e-4963-a001-9b6ca44d6a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8c60ac2f-db3a-47fe-aae6-268bb12733e7" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_e6f0b860-e85e-4963-a001-9b6ca44d6a0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b7b9aa2d-ed5f-4e31-b15f-9dd28aed6855" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_bf436b80-3d56-44a0-ad40-114f81ad1ba1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b7b9aa2d-ed5f-4e31-b15f-9dd28aed6855" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_bf436b80-3d56-44a0-ad40-114f81ad1ba1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_2bdaaffb-d849-492a-aaee-691d5099c848" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b7b9aa2d-ed5f-4e31-b15f-9dd28aed6855" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_2bdaaffb-d849-492a-aaee-691d5099c848" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_1932415f-d478-40cf-9fb2-ffda3bd3ca17" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b7b9aa2d-ed5f-4e31-b15f-9dd28aed6855" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_1932415f-d478-40cf-9fb2-ffda3bd3ca17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_da006235-0a99-4d84-a98b-470fbf09694f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_NetIncomeLoss_da006235-0a99-4d84-a98b-470fbf09694f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_ef27dd0b-ec6f-4f5b-902a-279127c48fa0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedTaxesPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_ef27dd0b-ec6f-4f5b-902a-279127c48fa0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncreaseDecreaseInAccruedSettlementLitigationLiabilities_f55b3b22-41cf-4049-a40c-c777ca7f9a94" xlink:href="cort-20241231.xsd#cort_IncreaseDecreaseInAccruedSettlementLitigationLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_cort_IncreaseDecreaseInAccruedSettlementLitigationLiabilities_f55b3b22-41cf-4049-a40c-c777ca7f9a94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_d04518d6-8f33-4540-a85d-7645cdbe1513" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_d04518d6-8f33-4540-a85d-7645cdbe1513" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_5e4e1282-b8e9-4e99-aa51-079fb79c0486" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_5e4e1282-b8e9-4e99-aa51-079fb79c0486" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_31c888b9-e200-4ccf-a5bc-015f735149a3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_31c888b9-e200-4ccf-a5bc-015f735149a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_c9f9e0a1-771b-42f5-9d9d-34d12a73d22a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_ShareBasedCompensation_c9f9e0a1-771b-42f5-9d9d-34d12a73d22a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_791460a9-f11e-4a2c-815c-28b0d85ffdf2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_791460a9-f11e-4a2c-815c-28b0d85ffdf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_addef6ec-d719-4c27-8611-308c44b7f0e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_addef6ec-d719-4c27-8611-308c44b7f0e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses_8b280773-f983-4cbb-9d09-bd22087e5dbb" xlink:href="cort-20241231.xsd#cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses_8b280773-f983-4cbb-9d09-bd22087e5dbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_a6f1ed7e-073f-451f-bc42-5531cf9e3443" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_a6f1ed7e-073f-451f-bc42-5531cf9e3443" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncreaseDecreaseInInsuranceRecoveryReceivable_d0bcc537-4dfd-4e69-9615-4eb681b898ce" xlink:href="cort-20241231.xsd#cort_IncreaseDecreaseInInsuranceRecoveryReceivable"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_cort_IncreaseDecreaseInInsuranceRecoveryReceivable_d0bcc537-4dfd-4e69-9615-4eb681b898ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_af1670ec-e19f-4be3-898d-d1fdfb422ecd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_af1670ec-e19f-4be3-898d-d1fdfb422ecd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f4bdbfc4-a9a6-40f3-9b31-9bda7337fa69" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f4bdbfc4-a9a6-40f3-9b31-9bda7337fa69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_327a1106-10ad-4837-a765-e67544e0b1df" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_327a1106-10ad-4837-a765-e67544e0b1df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_ce2cf26e-65f6-4773-a844-a6f03b10b206" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_ce2cf26e-65f6-4773-a844-a6f03b10b206" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_9f02238e-0d63-479a-8a09-9eb5156dfc10" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_40975244-4d28-479f-a068-11a1c6921e94" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_9f02238e-0d63-479a-8a09-9eb5156dfc10" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b01f055e-dc45-47fa-b712-10207e4e6ad5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_63cf919f-56f4-4a4d-8c2b-8b0e932c24f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b01f055e-dc45-47fa-b712-10207e4e6ad5" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_63cf919f-56f4-4a4d-8c2b-8b0e932c24f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d6213d2e-9367-4f11-8429-b14c7fbdd4af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b01f055e-dc45-47fa-b712-10207e4e6ad5" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d6213d2e-9367-4f11-8429-b14c7fbdd4af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_954e5873-7b21-4b3b-9a95-788c8cf9dcde" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b01f055e-dc45-47fa-b712-10207e4e6ad5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_954e5873-7b21-4b3b-9a95-788c8cf9dcde" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryCurrentNoncurrent_fcad04c4-bc74-4dc7-a96b-876320cf3d63" xlink:href="cort-20241231.xsd#cort_InventoryCurrentNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryWorkInProcessCurrentAndNoncurrent_150420fc-6fc2-422f-91ba-c3444c023b9e" xlink:href="cort-20241231.xsd#cort_InventoryWorkInProcessCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_fcad04c4-bc74-4dc7-a96b-876320cf3d63" xlink:to="loc_cort_InventoryWorkInProcessCurrentAndNoncurrent_150420fc-6fc2-422f-91ba-c3444c023b9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryFinishedGoodsCurrentAndNoncurrent_f65170e3-3a07-41e5-8aa4-6d9e6e0e9fc1" xlink:href="cort-20241231.xsd#cort_InventoryFinishedGoodsCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_fcad04c4-bc74-4dc7-a96b-876320cf3d63" xlink:to="loc_cort_InventoryFinishedGoodsCurrentAndNoncurrent_f65170e3-3a07-41e5-8aa4-6d9e6e0e9fc1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1" xlink:type="simple" xlink:href="cort-20241231.xsd#CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryCurrentNoncurrent_b92bfd52-d18b-44cb-87bf-2403a0d514dc" xlink:href="cort-20241231.xsd#cort_InventoryCurrentNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_2be41599-7db5-46ba-8324-c894c32ee4fe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_b92bfd52-d18b-44cb-87bf-2403a0d514dc" xlink:to="loc_us-gaap_InventoryNoncurrent_2be41599-7db5-46ba-8324-c894c32ee4fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_af983c16-fbac-4c23-89c6-cb9a74333cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_b92bfd52-d18b-44cb-87bf-2403a0d514dc" xlink:to="loc_us-gaap_InventoryNet_af983c16-fbac-4c23-89c6-cb9a74333cb6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_99513c93-ac1e-4da2-b8ae-0624dffb9157" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_ClinicalDepositsCurrent_6ba348d8-bdc5-4996-8499-62c67e8f465c" xlink:href="cort-20241231.xsd#cort_ClinicalDepositsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_99513c93-ac1e-4da2-b8ae-0624dffb9157" xlink:to="loc_cort_ClinicalDepositsCurrent_6ba348d8-bdc5-4996-8499-62c67e8f465c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_1d560e90-a97c-476c-9f04-355efee75b75" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_99513c93-ac1e-4da2-b8ae-0624dffb9157" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_1d560e90-a97c-476c-9f04-355efee75b75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_91759dd6-3bcb-4c21-a3ac-8583d52347a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_99513c93-ac1e-4da2-b8ae-0624dffb9157" xlink:to="loc_us-gaap_OtherAssetsCurrent_91759dd6-3bcb-4c21-a3ac-8583d52347a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_DeferredClinicalMaterialsCurrent_c645652d-66ea-4813-b8cf-d72eab903fb3" xlink:href="cort-20241231.xsd#cort_DeferredClinicalMaterialsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_99513c93-ac1e-4da2-b8ae-0624dffb9157" xlink:to="loc_cort_DeferredClinicalMaterialsCurrent_c645652d-66ea-4813-b8cf-d72eab903fb3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedLegalFeesCurrent_b3f3e582-3bd5-4ccb-816b-a3ad1c6179a0" xlink:href="cort-20241231.xsd#cort_AccruedLegalFeesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_cort_AccruedLegalFeesCurrent_b3f3e582-3bd5-4ccb-816b-a3ad1c6179a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedManufacturingCostsCurrent_13276ccc-eda3-49cc-a670-83f4009e7b9e" xlink:href="cort-20241231.xsd#cort_AccruedManufacturingCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_cort_AccruedManufacturingCostsCurrent_13276ccc-eda3-49cc-a670-83f4009e7b9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedGovernmentRebateCurrent_19a8cc22-6427-4c71-a4a5-73f1d5a56650" xlink:href="cort-20241231.xsd#cort_AccruedGovernmentRebateCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_cort_AccruedGovernmentRebateCurrent_19a8cc22-6427-4c71-a4a5-73f1d5a56650" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_ebaad7fa-e6c1-4407-9f01-fe46cebb022d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_ebaad7fa-e6c1-4407-9f01-fe46cebb022d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_39ade2d0-d03e-4f1a-9e3e-a0edbc01fb42" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_39ade2d0-d03e-4f1a-9e3e-a0edbc01fb42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedCompensationCurrent_923749f3-98c6-4c5b-8de4-14671d9c5a9a" xlink:href="cort-20241231.xsd#cort_AccruedCompensationCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_cort_AccruedCompensationCurrent_923749f3-98c6-4c5b-8de4-14671d9c5a9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesAndExciseTaxPayableCurrent_db0071dd-a17d-4024-8363-3d411f3b4c09" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SalesAndExciseTaxPayableCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_us-gaap_SalesAndExciseTaxPayableCurrent_db0071dd-a17d-4024-8363-3d411f3b4c09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_e55c3861-13d1-4f6c-a5bf-774b9e835010" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_e55c3861-13d1-4f6c-a5bf-774b9e835010" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_ffbd5d72-78b1-4689-bd49-f53bad7e797a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01c6944f-5b01-4fcf-b477-fd5e4f12a389" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_ffbd5d72-78b1-4689-bd49-f53bad7e797a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_78ac8c5c-2d41-485f-8d64-46e5f36f604a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_e10f6dae-d933-4bbf-8d31-c5590089840b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_78ac8c5c-2d41-485f-8d64-46e5f36f604a" xlink:to="loc_us-gaap_OperatingLeaseLiability_e10f6dae-d933-4bbf-8d31-c5590089840b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_a9cfd95d-893a-4c51-ab1b-5fbf9ca62152" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_78ac8c5c-2d41-485f-8d64-46e5f36f604a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_a9cfd95d-893a-4c51-ab1b-5fbf9ca62152" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="cort-20241231.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8687917d-1daf-42bf-92ca-de60e1a25488" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8687917d-1daf-42bf-92ca-de60e1a25488" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_d995a56e-715c-40c8-be98-92ea7a9c6a95" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_d995a56e-715c-40c8-be98-92ea7a9c6a95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_2d5bb215-76f8-40dc-8482-b3a1cb996098" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_2d5bb215-76f8-40dc-8482-b3a1cb996098" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_534c5944-9c49-40a4-9482-b5c1b857e2fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_534c5944-9c49-40a4-9482-b5c1b857e2fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_e92be635-5aa7-4393-babc-2fe386ca95fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_e92be635-5aa7-4393-babc-2fe386ca95fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_1a0e0810-1974-48bd-96ba-1d8dee114219" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2e147036-c25c-4fdc-8941-3ec06f991430" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_1a0e0810-1974-48bd-96ba-1d8dee114219" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/StockholdersEquityScheduleofStockBasedCompensationDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#StockholdersEquityScheduleofStockBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/StockholdersEquityScheduleofStockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_f61877b9-c7db-4532-ba69-85386a7d0862" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_fa817801-906a-4ba6-95f2-0c6943291b03" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_f61877b9-c7db-4532-ba69-85386a7d0862" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_fa817801-906a-4ba6-95f2-0c6943291b03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_a576f28f-6b55-4907-b49e-4a7a13d3548a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_f61877b9-c7db-4532-ba69-85386a7d0862" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_a576f28f-6b55-4907-b49e-4a7a13d3548a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/NetIncomePerShareScheduleofComputationofNetIncomeLossPerShareDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#NetIncomePerShareScheduleofComputationofNetIncomeLossPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/NetIncomePerShareScheduleofComputationofNetIncomeLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1ab81a68-64e7-4721-aafb-e5d3dcf0f519" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fcfc403e-fb76-4179-b9ab-39e67a25fff7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1ab81a68-64e7-4721-aafb-e5d3dcf0f519" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fcfc403e-fb76-4179-b9ab-39e67a25fff7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_7660cd5b-f54b-446b-a17a-a253ddae9cae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1ab81a68-64e7-4721-aafb-e5d3dcf0f519" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_7660cd5b-f54b-446b-a17a-a253ddae9cae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/IncomeTaxesScheduleofComponentsofincomeTaxBenefitDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#IncomeTaxesScheduleofComponentsofincomeTaxBenefitDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/IncomeTaxesScheduleofComponentsofincomeTaxBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e6e29c61-7695-4221-9cef-51306809f9c6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_dced7cef-2c03-4af3-824d-a530b596753f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e6e29c61-7695-4221-9cef-51306809f9c6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_dced7cef-2c03-4af3-824d-a530b596753f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_a8679abb-a8ea-40d4-9d52-15d189134efc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e6e29c61-7695-4221-9cef-51306809f9c6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_a8679abb-a8ea-40d4-9d52-15d189134efc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxBenefitDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#IncomeTaxesScheduleofComponentsofIncomeTaxBenefitDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_6d394eed-637b-4f42-9556-6a8a16af406e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_b6b2bee6-f23c-49c3-8a56-352ebd725b16" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_6d394eed-637b-4f42-9556-6a8a16af406e" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_b6b2bee6-f23c-49c3-8a56-352ebd725b16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_9e5164c5-48ea-4f1b-96d2-781301263965" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_6d394eed-637b-4f42-9556-6a8a16af406e" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_9e5164c5-48ea-4f1b-96d2-781301263965" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_ca72501c-9c96-4e8a-9c48-0102d2e652a7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_8d65c41d-7118-462e-9eb0-b23759677f33" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_ca72501c-9c96-4e8a-9c48-0102d2e652a7" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_8d65c41d-7118-462e-9eb0-b23759677f33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_73114609-3f3e-4c3c-9618-e9558c7dfac9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_ca72501c-9c96-4e8a-9c48-0102d2e652a7" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_73114609-3f3e-4c3c-9618-e9558c7dfac9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_bba0a891-656b-4f86-9549-56cf527d631e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_47ed8d6f-205b-454f-9c07-2b72bb835e77" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_bba0a891-656b-4f86-9549-56cf527d631e" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_47ed8d6f-205b-454f-9c07-2b72bb835e77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_89cd47e2-a640-4cab-b8a0-9f96e2f4bc20" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_bba0a891-656b-4f86-9549-56cf527d631e" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_89cd47e2-a640-4cab-b8a0-9f96e2f4bc20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_e12e4828-7995-4fcf-b1a5-455aa36e5c11" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_de880a30-f261-49fa-a2a9-460a0b33b7fe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_e12e4828-7995-4fcf-b1a5-455aa36e5c11" xlink:to="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_de880a30-f261-49fa-a2a9-460a0b33b7fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_14dfe637-98c1-4890-b949-98017f1b8996" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_e12e4828-7995-4fcf-b1a5-455aa36e5c11" xlink:to="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_14dfe637-98c1-4890-b949-98017f1b8996" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_bdf58f57-a9fc-4873-b47f-909aa3f5f718" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_e12e4828-7995-4fcf-b1a5-455aa36e5c11" xlink:to="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_bdf58f57-a9fc-4873-b47f-909aa3f5f718" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/IncomeTaxesScheduleofSignificantComponentsofDeferredTaxAssetsDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#IncomeTaxesScheduleofSignificantComponentsofDeferredTaxAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/IncomeTaxesScheduleofSignificantComponentsofDeferredTaxAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_5fc80437-c7af-4fc5-b1a7-a116ab4bc591" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_4ac1e29b-0a33-44b6-a3d4-069993d5f025" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_5fc80437-c7af-4fc5-b1a7-a116ab4bc591" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_4ac1e29b-0a33-44b6-a3d4-069993d5f025" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_82f416c5-c266-4255-90a5-4318c114787c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_5fc80437-c7af-4fc5-b1a7-a116ab4bc591" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_82f416c5-c266-4255-90a5-4318c114787c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_f318e382-f836-4822-a46a-877bf6d1a59a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_5fc80437-c7af-4fc5-b1a7-a116ab4bc591" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_f318e382-f836-4822-a46a-877bf6d1a59a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_fe251d88-bd66-451f-bcbe-b8fff8281114" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_668f5d93-5f30-463f-9bed-b51d973423e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_fe251d88-bd66-451f-bcbe-b8fff8281114" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_668f5d93-5f30-463f-9bed-b51d973423e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_1c8c98e4-dfd5-4442-95a9-63ae85223184" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_fe251d88-bd66-451f-bcbe-b8fff8281114" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_1c8c98e4-dfd5-4442-95a9-63ae85223184" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_d859260e-5c6a-46bf-a4ea-37074ebe470c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_d859260e-5c6a-46bf-a4ea-37074ebe470c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_DeferredTaxAssetsCapitalizedResearchExpenditures_bab2e984-347d-4366-8e3e-40fcc2fbd1b1" xlink:href="cort-20241231.xsd#cort_DeferredTaxAssetsCapitalizedResearchExpenditures"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_cort_DeferredTaxAssetsCapitalizedResearchExpenditures_bab2e984-347d-4366-8e3e-40fcc2fbd1b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_b8212f4d-f1cc-4cda-86d3-26bc04ddc25f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_b8212f4d-f1cc-4cda-86d3-26bc04ddc25f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_DeferredTaxAssetsOperatingLeaseLiability_d346b002-11db-400a-b036-b1584e77567c" xlink:href="cort-20241231.xsd#cort_DeferredTaxAssetsOperatingLeaseLiability"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_cort_DeferredTaxAssetsOperatingLeaseLiability_d346b002-11db-400a-b036-b1584e77567c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_abfa36e5-12c7-4331-8162-6fac818cdc2d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_abfa36e5-12c7-4331-8162-6fac818cdc2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_2bcac765-8aa0-493c-b865-7088548fb79b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_2bcac765-8aa0-493c-b865-7088548fb79b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_824a8cdc-1243-4d86-94f4-5535a443c0ba" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_824a8cdc-1243-4d86-94f4-5535a443c0ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts_0e37770e-1c3c-4a90-a23f-721ab40293df" xlink:href="cort-20241231.xsd#cort_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8902b64b-efd9-48a8-99d7-9d9124584de4" xlink:to="loc_cort_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts_0e37770e-1c3c-4a90-a23f-721ab40293df" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/IncomeTaxesScheduleofReconciliationofStatutoryFederalIncomeTaxRatetoEffectiveRateDetails" xlink:type="simple" xlink:href="cort-20241231.xsd#IncomeTaxesScheduleofReconciliationofStatutoryFederalIncomeTaxRatetoEffectiveRateDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/IncomeTaxesScheduleofReconciliationofStatutoryFederalIncomeTaxRatetoEffectiveRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_15a9146c-ff9b-420f-887d-56282550dd18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_15a9146c-ff9b-420f-887d-56282550dd18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_bf26ba45-05a2-4760-a7ba-8c32a5636848" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_bf26ba45-05a2-4760-a7ba-8c32a5636848" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_b732b0a8-4bb8-4d62-a237-369064b03d90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_b732b0a8-4bb8-4d62-a237-369064b03d90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncomeTaxReconciliationNondeductibleExpenseCompensationCost_8e0e20a3-72e0-4ff7-9a1a-19d9ff6d6961" xlink:href="cort-20241231.xsd#cort_IncomeTaxReconciliationNondeductibleExpenseCompensationCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_cort_IncomeTaxReconciliationNondeductibleExpenseCompensationCost_8e0e20a3-72e0-4ff7-9a1a-19d9ff6d6961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncomeTaxReconciliationNondeductibleExpenseBenefitShareBasedCompensation_65afa46b-585b-423f-8f56-e86faaa6d1b2" xlink:href="cort-20241231.xsd#cort_IncomeTaxReconciliationNondeductibleExpenseBenefitShareBasedCompensation"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_cort_IncomeTaxReconciliationNondeductibleExpenseBenefitShareBasedCompensation_65afa46b-585b-423f-8f56-e86faaa6d1b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_c91c999b-17fc-4442-b800-8c4071df50ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c7875ce5-2f1e-4582-90fb-f6f5971c009a" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_c91c999b-17fc-4442-b800-8c4071df50ea" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
